Proteolysis and Proteolytic Pathways – Life After the Point of No Return
Sergey A. Shiryaev, Alex Y. Strongin
Abstract
Proteolysis is the irreversible post-translational modification affecting a specific peptide bond in a target protein substrate. This event normally leads to a loss or gain of function in the proteolyzed protein. Limited proteolysis is widely used to regulating almost all of the known biological pathways in living organisms. Over 500 specialized protease enzymes, one of the largest classes of enzymes, are encoded by the human genome. The proteolysis is “a one-way road” process that cannot be turned back or start all over again. During the proteolysis the target protein has to pass some kind of “the point of no return”, after which, it will be directed on the principally new way or the new step of its life. At the molecular level, proteolysis accompanies multiple steps of the proteins’ life, normally, from the very first and to the very last stages...
J. Proteolysis Vol 1, No 1 (2014); doi:10.13176/14.609 | Full Text: PDF | Share this paper: